Application

Research Sub CategoryNuclear Receptors

Research CategoryEpigenetics & Nuclear Function

Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected B-cell lymphoma/leukemia 11B in Jurkat cells.

Anti-B-cell lymphoma/leukemia 11B, clone 3A8.2 is an antibody against B-cell lymphoma/leukemia 11B for use in WB, ICC.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

B-cell lymphoma/leukemia 11B, also known as B-cell lymphoma/leukemia 11B (BCL-11B), B-cell CLL/lymphoma 11B, COUP-TF-interacting protein 2, Radiation-induced tumor suppressor gene 1 protein, hRit1, and encoded by the gene name BCL11B/ CTIP2/ RIT1, is a tumor-suppressor protein involved in t-cell lymphomas. B-cell lymphoma/leukemia 11B have been shown to play a role in the p53-signaling pathway. B-cell lymphoma/leukemia 11B may be a key regulator of both differentiation and survival during thymocyte development. B-cell lymphoma/leukemia 11B represses transcription through direct, tfcoup2-independent binding to a gc-rich response element. B-cell lymphoma/leukemia 11B interacts with tfcoup1, sirt1, arp1 and ear2. B-cell lymphoma/leukemia 11B is highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.

Immunogen

GST-tagged recombinant protein corresponding to human B-cell lymphoma/leukemia 11B.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected B-cell lymphoma/leukemia 11B in 10 µg of Jurkat cell lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~94 and ~86 kDa observed